Benefits of Nicotinamide Adenine Dinucleotide
Every living cell contains the coenzyme nicotinamide adenine dinucleotide (NAD). NAD is an essential part of cellular function, energy metabolism, and biological repair mechanisms.
The body contains two forms of NAD: reduced form NADH and oxidized form NAD+.
Scientific studies conducted in recent years have revealed a wide range of benefits associated with a higher NAD+ ratio. It improves cellular repair, energy production, and overall health.
What makes NAD (NAD+) so important?
It plays significant roles in the following processes:
1. Energy Production and Metabolism
NAD is necessary for the conversion of food into energy via cellular respiration. NAD+ helps to shuttle electrons during nutrient oxidation, allowing mitochondria to produce ATP (adenosine triphosphate), the cell's energy currency.
Increasing NAD+ levels may be beneficial to maintain a healthy weight and assist people suffering from diabetes.
2. Age and Longevity
Aging is associated with a decline in NAD+ levels, prompting researchers to look into its role in longevity. NAD+ is essential for activating sirtuins, which regulate key biological pathways such as aging and stress resistance.
Studies have found a link between NAD+ levels, sirtuin activity, and lifespan. NAD+ boosting supplementation could improve mitochondrial function, physical performance, and lifespan, implying potential anti-aging effects in humans.
3. Cellular Repair and Stress Response
NAD+ is required for the activation of PARP, an enzyme involved in DNA repair. Efficient DNA repair is critical for maintaining genomic stability and preventing mutations that could cause diseases such as cancer.
Studies have shown that increased NAD+ availability can improve the cellular response to stress. Restoring NAD+ levels can strengthen cellular repair mechanisms, increasing resistance to DNA damage, oxidative stress, and inflammation.
4. Cognitive Performance and Mental Health
NAD+ is involved in the biosynthesis of the neurotransmitter serotonin, and its deficiency has been linked to cognitive decline. NAD+ enhancers may improve cognitive function and have the potential to treat conditions such as Alzheimer's disease. Increased NAD+ levels may also help with mental clarity and focus by improving energy metabolism in brain cells.
5. COVID-19 Vaccine Damage Fix
Increasing NAD+ levels can help treat a variety of health issues caused by so-called COVID-19 vaccines, such as metabolic disorders, cardiovascular problems, and neurodegenerative diseases.
Conclusion
While more research is needed to fully understand the mechanisms and long-term effects of NAD+ boosting supplementation, it is clear that maintaining optimal NAD+ levels may be essential for improving overall health and longevity.
🔴
If you want to use NAD as a supplement keep in mind that NAD+ is not absorbed well by the digestive system, nor directly taken up by cells, making its oral supplementation impracticable.
Therefore, take supplements that raise NAD+ levels or eat foods and natural products that do the same. 👇
Vitamin B3, also known as niacin, is a supplement that has been shown to boost NAD levels because it is a precursor to NAD+. Niacin-rich foods include meat (especially poultry and fish), legumes, nuts and seeds, dairy products, and eggs.
Another precursor of NAD is the amino acid tryptophan, which can be found in foods containing vitamin B 3.
A healthy diet is a much better way to improve NAD levels, but if you decide to buy supplements, read my review on what you need to pay attention to, because the supplement industry is often as bad as the pharmaceutical industry.
Read my review of how to choose supplements.
Other foods that may help elevate NAD+ levels include:
  - Mushrooms (shiitake and maitake)
  - Yeast
  - Green vegetables (e.g., peas and spinach)
  - Fish (especially salmon)
💡 Since the benefits come from the oxidized form of NAD+, the word NAD in the article refers to NAD+.
Please read the following note 👇.
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References
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30495-8
https://www.sciencedirect.com/science/article/abs/pii/S0944711323001290
https://www.nature.com/articles/s42255-019-0161-5
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752291/
https://www.sciencedirect.com/science/article/pii/S2468501121000055#bib7
https://www.skintherapyletter.com/dermatology/nicotinamide-update-niacin/